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Celprogen's Publications

 

  
Publications by Category:


Mouse Endothelial Cell culture:

  • Csiszar, Anna, Zoltan Ungvari, Akos Koller, and John G. Edwards, et al. "Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging." Physiol Genomics. 17(2004): 21-30. 
    Download Full Article... pdf


 

  • Csiszar, Anna, Nazar Labinskyy, Kira E. Smith, and Aracelie Rivera, et al.. "Downregulation of Bone Morphogenetic Protein 4 Expression in Coronary Arterial Endothelial Cells Role of Shear Stress and the cAMP/Protein Kinase A Pathway:." Journal of the American Heart Association. 27(2007): 776-782. Downloan Article... pdf

  • Csiszar, Anna, Mansoor Ahmad, Kira E. Smith, and Nazar Labinskyy,et al.. "Bone Morphogenetic Protein-2 Induces Proinflammatory Endothelial Phenotype." Vascular Biology, Atherosclerosis and Endothelium Biology. 168(2006): 629-638. Download Article... pdf

  • Ungvari, Zoltan, Zsuzsanna Orosz, Nazar Labinskyy, and Aracelie Rivera, et al. " Mitochondrial H2O2 production promotes endothelial activation in aged rat arteries." Am J Physiol Heart Circ Physiol.293(2006): H37-H47. View Article... pdf

  • Csiszar MD, PhD;, Anna, Kira E. Smith, Akos Koller, MD, PhD, and Gabor Kaley, et al. "Regulation of Bone Morphogenetic Protein-2 Expression in Endothelial Cells Role of Nuclear Factor Activation by Tumor Necrosis Factor, H2O2,and High Intravascular Pressure." Circulation. (2005): 2364-2372. 
    View Article... pdf


Rat Hepatic Embryonic Stem Cells:

  • Nikolic, Boris and Mostafa Elian. "The Effect of Hepatic Radiofrequency Ablation on Stem Cell Trafficking in Rat ModelContinuing Medical Education - 2009 640-47. Jul 2009... View Article pdf

  • Sharma, Cristian, Michael V.R. Sharma, Rafael Perez, and Chrystal Johnson, et al. "Transplants of Human Embryonic Stem Cells (HESC) Improved Motor Function recovery in Spinal Cord Injured rats." View Article... pdf


Human Cancer Stem Cells:

  • Brahma N. SIngh, Junsheng Fu, Rakesh K. Srivastava, Sharmila Shankar; "Hedgehog Signaling Antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: Molecular mechanisms"; Plos One Journal, November 2011; Volume 6 Isuue 11. View Article
  • C. DiMaggio1, M. Majdoub1, S. Sharma1, N. Amezcua1, J. Passarini1, C. Sharma1, M. Sharma1, M.E. Harris-White1, S. Sharma1, R. Punzalan1, O. Sobhy1, M. Warden1, J. Sharma1"Human Triple Negative Breast Cancer Stem Cells Utilized for Drug Discovery Therapeutics for Triple Negative Breast Cancer Patients101st Annual Meeting - The American Association for Cancer Research. - View Poster...  
     

  • Klarmann , GJ, et al.. "Invasive prostate cancer cells are tumor initiating cells that have a stem cell-like genomic signature..Clin Exp Metasis 2617 Feb 2009 433-46. Web.9 Jul 2009... View Article pdf

  • Brian T. Kawasaki, Elaine M. Hurt, Madhuri Kalathur, Maria Ana Duhagon, John A. Milner, Young S. Kim and William L. Farrar "Effects of the Sesquiterpene Lactone Parthenolide on Prostate Tumor-Initiating Cells: An Integrated Molecular Profiling Approach" (2009)...  View Article pdf
     

  • Marni E. Harris-White (UCLA), Pramod Sutrave, Mariam W. Majdoub, Natalie M. Liles, Nina R. Taw, Gabriel P. Velázquez, Christina M. DiMaggio, Cristian R. Sharma, Michael R. Sharma, Shaleekha K. Sharma, Rubio R. Punzalan, Shavendra P. Sharma(UCLA), Jay P. Sharma"Brain Cancer Stem Cells as a potential research and therapeutic target in treatment of Glioblastoma Multiforme (GBM)" (2009)... View Poster  - View Abstract pdf

  • Sharma, Jay, Rubio R. Punzalan, Mariam W. Majdoub, and Natalie M. Liles, et al. "Brain Cancer Stem Cells as potential research and therapeutic target in treatment of Glioblastoma Multiforme (GBM)." Tumor Biology.(2009). View Article... pdf

  • Cancer Stem Cells being utilized in Cell-based assay screening in the development of Novel Anti-Cancer Drug Candidates for organ-specific tumor therapy... View abstract... 

  • Jung-Hynes, Brittney, Minakshi Nihal, Weixiong Zhong, and Nihal Ahmad, et al.. "Role of sirtuin histone deacetylase Sirt1 in prostate cancer: A target for prostate cancer management via its inhibition?."The Journal of Biological Chemistry. (2008): 1-25... View Article... pdf

  • M. E. Harris-White1, P. Sutrave3, M. W. Majdoub3, N. M. Liles3, N. R. Taw3, G. P. Velazquez3, C. M. Dimaggio3, C. R. Sharma3, M. R. Sharma3, S. K. Sharma3, R. R. Punzalan3, J. P. Sharma3, S. P. Sharma3; 1UCLA/VA-GLAHS, Sepulveda, CA; 2UCLA/VA-GLAHS, West Los Angeles, CA; 3CelProgen, Inc., San Pedro, CA "Signaling pathways for the maintenance of glioblastoma In Vivo" - View Poster... pdf

  • J. Sharma1, R. Punzalan1, C. DiMaggio1, N. Taw1, M. Majdoub1, N. Liles1, G. Velazquez1, S. Sharma1, N. Amezcua1, K. DeSimone1, C. Sharma1, M. Sharma1, M. J. Jani1, S. Sharma1"Human HER2+ Breast Cancer Stem Cells Utilized for Drug Discovery Therapeutics for HER2+ and Estrogen & Progesterone Negative Breast Cancer Patients" 49th Annual Meeting - The American Society for Cell Biology (2009) View abstract... pdf - View Poster... 
     

  • J. Sharma1, C. DiMaggio1, N. Taw1, M. Majdoub1, N. Liles1, G. Velazquez1, N. Amezcua1, C. Sharma1, M. Sharma1 "Human Liver Cancer stem cells as a potential target for novel drug therapy and drug discovery49th Annual Meeting - The American Society for Cell Biology. View abstract... pdf - View Poster... 
     

  • J. Sharma1, R. Punzalan1, C. DiMaggio1, N. Taw1, M. Majdoub1, N. Liles1, G. Velazquez1, S. Sharma1, N. Amezcua1, C. Sharma1, M. Sharma1, S. Sharma2 "Human Pancreatic Cancer Stem Cell Utilized in Cell Based Assay system for Screening Novel and Potential Drug Candidates for Pancreatic Cancer Patients49th Annual Meeting - The American Society for Cell Biology. View abstract... pdf - View Poster... 
     

  • J. Sharma1, C. DiMaggio1, N. 1, M. Majdoub1, N. Liles1, G. Velazquez1, S. Sharma1, N. Amezcua1, K. DeSimone1, C. Sharma1, M. Sharma1, S. Sharma1, R. Punzalan1 "Human Triple Negative Breast Cancer Stem Cells Utilized for Drug Discovery Therapeutics for Triple Negative Breast Cancer Patients49th Annual Meeting - The American Society for Cell Biology. View abstract... pdf - View Poster... 

  • John P. Cleary, Michael Sharma, Estaban J. Gomez, Cristian Sharma, Shruthi Satish, Aabha Khemani, Rubio Punzalan, Jitesh Jani, Mariam Navel, Natalee Amezcua, Jay Sharma; "Optimal Drug Concentration Screening and Evaluation in Cancer Stem Cells & 3D Tumor Stem Cell Cultures Drug Response Assays in Association with Clinical Efficacy for Pancreatic Cancer Stem Cells"; American Association for Cancer Research, AACR Annual Meeting 2013.    View Poster 

    Rajani Kanteti, Essam El-Hashani, Immanuel Dhanasingh, Maria Tretiakova, Aliya N Husain, Sherven Sharma, Jay Sharma, Everett E Vokes and Ravi Salgia; "Role of PAX8 in the regulation of MET and RON receptor tyrosine kinases in non-small cell lung cancer." View Publication 

     


Human Cardiomyocytes:

  • Infomational Session: "Correlation of Kinase-Inhibitor Cardiotoxicity to Kinase specificity profiles" Kyle L. Kolaja - Abstract# 1636 at the 48th Annual Meeting and ToxExpo in Baltimore, MD. March 15-19, 2009.

  • H. Uppal, D. Puppala, M. Sweeney, P. Dhawan, J. Jin, R. Varma, H. Bitter, D. Goldstein, D. Misner, S. Platz and K. Kolaja. "Potential mechanisms of In vitro Cardiotoxicity associated with Tyrosine Kinase inhibitors"Presented By ROCHE Pharmaceutical - Poster# 442 Presented at the 48th Annual Meeting and ToxExpo in Baltimore, MD. March 15-19, 2009.

  • M.D. Sweeney, D. Puppala, H. Uppal, N.M. Liles, M.W. Majdoub, J. Sharma, S. Kaushal, M. Fielden and K. Kolaja."Characterization of primary Human Cardiomyocytes as a potential In vitro model for testing Cardiotoxicity" Presented By ROCHE Pharmaceutical - Poster# 441 Presented at the 48th Annual Meeting and ToxExpo in Baltimore, MD. March 15-19, 2009.

  • P. Dhawan¹, S. Yaung³, H. Uppal¹, D. Puppala¹, M. Sweeney¹, J. Murray³, P. Hajek³, E. Oquendo³, C. Wilson³, N. Priedigkeit³, D. Goldstein², D. Misner¹, S. Platz¹, R. Calpadi³ and K. Kolaja¹. "The role of Mitochondrial toxicity in The Cardiotoxicity of small molecule Kinase inhibitors" Presented By ROCHE Pharmaceutical - Poster# 435 Presented at the 48th Annual Meeting and ToxExpo in Baltimore, MD. March 15-19, 2009.

  • D. Puppala¹, H. Uppal¹, P. Dhawan¹, D. Goldstein², D. Misner¹ and K. L. Kolaja¹. "Investigating the mechanisims of Cardiotoxicity with Tyrosine Kinase inhibitors using primary Human Cardiomyocytes"  Presented By ROCHE Pharmaceutical - Poster# 434 Presented at the 48th Annual Meeting and ToxExpo in Baltimore, MD. March 15-19, 2009.

  • L. Plonchuk¹, J. Ly, J. Jin², M. Sweeney², H. Uppal², K. Kolaja², A. Breidenbach¹ and D. Misner²."Electrophysiological Profiling of Cardiac Progenitors from Adult Human Myocardium" (2009) Presented By ROCHE Pharmaceutical - Poster# 328 Presented at the 48th Annual Meeting and ToxExpo in Baltimore, MD. March 15-19, 2009. 

  • D. L. Misner, J.Q. Ly, A. Orogo, H. Uppal, D. Button, S. Platz and K. Kolaja. "Development of Methods to image Calcium Transients in Human Cardiomyocytes" (2009) Presented By ROCHE Pharmaceutical - Poster# 320 Presented at the 48th Annual Meeting and ToxExpo in Baltimore, MD. March 15-19, 2009. 

  • Human Cardiomyocyte Stem Cells as an alternative to Cardiac tissue transplants. 
    American Society for Cell Biology 48th Annual Meeting, December 13-17th 2008, San Francisco, CA. Abstract# 2153,B6231... View abstract... pdf

  • Walter Campos, Dayaneethie Coopusamy, Lynn Morris, Bongani M Mayosi, and Makobetsa Khati*"Cytotoxicological analysis of a gp120 binding aptamer with cross-clade Human Immunodeficiency Virus Type-1 entry inhibition properties: a comparison to conventional antiretrovirals" Antimicrobial Agents and Chemotherapy, July 2009, p. 3056-3064, Vol. 53, No. 7 - CSIR Biosciences, PO Box 395, Pretoria, 0001, South Africa; National Institute for Communicable Diseases, Private Bag X4, Sandringham 2131, South Africa; Department of Medicine, Groote Schuur Hospital and University of Cape Town, Observatory 7925, South Africa - Cardiomyocytes were also purchased from Celprogen, USA. The cardiomyocytes were phenotyped by  immunocytochemistry using a cardiac specific monoclonal antibody that targets.
  • J.P. Cleary, E.J. Gomez, C.V. Sharma, M.V. Sharma, A.P. Khemani, R. Punzalan, M. Navel, N. Amezuca, J. Jani, J.P. Sharma, "Genetic and Pharmacological Properties of Human Cardiac Stem Cell- Derived Cardiomyocytes", The American Society for Cell Biology 2012 Annual Meeting. View Poster
  • Cristian Sharma1, , Michael Sharma1, Shawn Mallen1, Kristina Bergersen1, Natalee Amezcua1, Donna Stanton1, Miriam Navel1, Padmini Narayanan1, Robert Rodriguez1,Shaleekha Sharma1 , Mandana Amiri1,Sherven Sharma2, Jitesh. P. Jani1, Henry Wong3, Johar Kohana3, John Collins3 and Jay Sharma1 1Celprogen Inc., 3914 Del Amo Blvd., Torrance, California, USA ; 2Department of Medicine, UCLA/VAGLAHS Lung Cancer Research Program and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Molecular Gene Medicine Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.; 3 Biopico Systems Inc, Irvine, CA  View Poster
  • Eric A. Evangelista, Rudiger Kaspera, Nahush A. Mokadam, J.P. Jones, III, and Rheem A Totah (2013) Activity, Inhibition, and Induction of Cytochrome P450 2J2 in Adult Human Primary Cardiomyocytes. Drug Metab Dispos41: 2087-2094     Publication 
  • Cristian Sharma1, , Michael Sharma1, Shawn Mallen1, Kristina Bergersen1, Natalee Amezcua1, Donna Stanton1, Miriam Navel1, Padmini Narayanan1, Robert Rodriguez1,Shaleekha Sharma1 , Mandana Amiri1,Sherven Sharma2, Jitesh. P. Jani1, Henry Wong3, Johar Kohana3, John Collins3 and Jay Sharma1. 1Celprogen Inc., 3914 Del Amo Blvd., Torrance, California, USA ; 2Department of Medicine, UCLA/VAGLAHS Lung Cancer Research Program and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Molecular Gene Medicine Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.; 3 Biopico Systems Inc, Irvine, CA    Publication


Human Hepatocyte:

  • Kosuge, Kazuhiro, Andrew I. Chuang, Satoko Uematsu, and Kah Poh Tan et al.. "Discovery of Osmosensitive Transcriptional Regulation of Human Cytochrome P450 3As by the Tonicity-ResponsiveEnhancer Binding Protein (Nuclear Factor of Activated T Cells 5)." Molecular Pharmocology. 72(2007): 826-837. View Article... pdf
     

  • Tan, Kah Pon, Mingdong Yang,, Shinya Ito. "Activation of Nuclear Factor (Erythroid-2 Like) Factor 2 by Toxic Bile Acids Provokes Adaptive Defense Responses to Enhance Cell Survival at the Emergence of Oxidative Stress." Molecular Pharmocology. 71(2007): 1380-1390. View Article... pdf
     

  • American Society for Pharmacology and Experimental TherapeuticsMolecular Pharmacology Fast Forward. Published on August 27, 2007 as doi:10.1124/mol.107.039370. Activation of Nrf2 by Toxic Bile Acids Provokes Adaptive Defense Responses. To Enhance Cell Survival at the Emergence of Oxidative Stress. Kah Poh Tan, Mingdong Yang, and Shinya Ito Downloan Article... pdf

  • Lyudmila I. Rachek , Larysa V. Yuzefovych, Susan P. LeDoux Neil L. Julie and Glenn L. Wilson Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes Toxicology and Applied Pharmacology 24 July 2009. - Human Hepatocyte cell culture.

 

 

Human Cholangiocyte:

 

  • Alessia Omenetti,1 Alessandro Porrello,2 Youngmi Jung,1 Liu Yang,1 Yury Popov,3,4 Steve S. Choi,1 Rafal P. Witek,1 Gianfranco Alpini,5,6 Juliet Venter,6 Hendrika M. Vandongen,1 Wing-Kin Syn,1 Gianluca Svegliati Baroni,7 Antonio Benedetti,7 Detlef Schuppan,3 and Anna Mae Diehl Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest. 2008 October 1; 118(10): 3331–3342. Guoku Hu, Ai-Yu Gong, Jun Liu, Rui Zhou, Caishu Deng, and Xian-Ming Chen miR-221 suppresses ICAM-1 translation and regulates interferon-γ-induced ICAM-1 expression in human cholangiocytes. AJP - GI April 2010 vol. 298 no. 4 G542-G550 T Roskams. Liver stem cells and their implication in hepatocellular and cholangiocarcinoma. Oncogene (2006) 25, 3818–3822. doi:10.1038/sj.onc.1209558.

 


Human Peripheral Blood Cell Culture:

  • Zennadi, Rahima, Benjamin J. Moeller, Erin J. Whalen, and Milena Batchvarova ,et al. "Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo." Blood. 110(2007): 2708-2717. 
    View Article... pdf

Human Colon Cell Culture:

  • Zheng, Yan, Patricia A. Valdez, Dimitry M. Danilenko, and Yan Hu, et al.. "Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens." Nature Medicine. 14(2008): 282-289... 
    View Article... pdf


Mouse Embryonic Stem Cells:

  • Rogers, Ian, Robert Casper, and Ryszard Bielecki. "COMPOSITIONS AND METHODS FOR TREATING PERIPHERAL VASCULAR DISEASES." (2008). View Abstract... pdf

  • Meng, Guoliang, and Derrick Rancourt. "Methods and Materials for Culturing Murine Embryonic Stem Cells." Abstract. Methods and Materials for Culturing Murine Embryonic Cells (2009). View Patent... pdf


Human Stem Cells:

  • J.P.Sharma, H. eran, F.Byhower, C.R. Sharma, M.R. Sharma, M.R. Sharma, L.J. Byhower, K.A. Okbaok, N.J. Heidtbrink-Ramirez, N.Taw.. Human Amniotic Epithelial Cell as an Alternative source of Human Embryonic Stem Cells.Download Abstract... pdf


 

  • Abstract accepted at Stem Cell Research and Therapeutics Conference March 2 & 3, 2006. San Francisco, California.Synchronized Contracting Cardiomyocytes in culture from Human Cord Blood-Derived Stem Cells as a Potential source for Cardiomyocyte-Based Therapeutics and Alternative to Heart Transplantation.Download Abstract... pdf

  • Abstract accepted at Stem Cells Research and Therapeutics Conference April 11 & 12 2005 , San Diego, California.
    Human Cord Blood derived Stem Cells Differentiated into Hormone-Expressing Islet Cell-like Aggregates to Produce Insulin as an Alternative to Pancreatic transplant for diabetic and pancreatic Cancer PatientsDownload Abstract... pdf


 

  • Abstract accepted at 2005 American Association for Cancer Research (AACR) 96th Annual meeting in Anaheim, California. Late Breaking Abstract Submission # LB-128. Human Stem Cells Derived from Cord Blood Reduces the size of Pancreatic Tumor in SCID Mice Download Abstract... pdf


 

  • Abstract presented at SCBC, Investor conference, March 23, 2005; Los Angeles California. Human Cord Blood derived Stem Cells Differentiated into Hormone-Expressing Islet Cell-like Aggregates to Produce Insulin as an Alternative to Pancreatic transplant for diabetic and pancreatic Cancer Patients 
    Download Abstract... pdf


 

  • Boulaire, Jerome *; Zhao, Ying *; Wang, Shu *,+ Gene expression profiling to define host response to baculoviral transduction in the brain. Journal of Neurochemistry. 109(5):1203-1214, June 2009.
    Neuronal Stem cells trans-differentiation from Human Cord Blood Derived Stem Cells.

  • J. Sharma1, J. Wibbenmeyer2, L. Ugozzoli2, A. McCoy2, M. Collins2, S. Kaushal3, H. Uppal4, C. DiMaggio1, N. Taw1, M. Majdoub1, N. Liles1, G. Velazquez1, S. Sharma1, N. Amezcua1, K. DeSimone1, C. Sharma1, M. Sharma1 "Cardiac Stem Cells labeled with GFP protein to demonstrate engraftment in mouse model as an alternative potential cell based therapy for Cardiac Transplant Patients." - 49th Annual Meeting - The American Society for Cell Biology (2009) View abstract... pdf - View Poster... 


Extra-cellular Matrix:

  • Abstract accepted at The 45th Annual Meeting American Society for Cell Biology.   San Francisco, California Dec. 10-14 2005. Neuronal Cell Culture Matrix For Better Maintenance And Survival of Neuronal Cell Cultures In Tissue Culture Download Abstract... pdf


Nasopharyngeal Cells:

  • Alajez, Nehad, Joseph D.Mocanu, Wei Shi, and Marie C. Chia,et al. "Efficacy of Systemically Administered Mutant Vesicular Stomatitis (VSV#51) Combined with Radiation for Nasopharyngeal ." Clinical Cancer Research.14(2008): 4891-4897. View Article... pdf


Human Coronary Artery Endothelial Cells:

  • "Resveratrol induces Mitochondrial Biogenesis in Endothelila Cells". Csiszar et al. AM J Physiol Heart Circ Physiol. 2009; 297: H13-H2O. - human coronary arterial endothelial cells (CAECs)


Human Endothelial Progenitor Cells:

  • J. Sharma1, R. Punzalan1, C. DiMaggio1, N. Taw1, M. Majdoub1, N. Liles1, G. Velazquez1, S. Sharma1, N. Amezcua1, C. Sharma1, M. Jani1, M. Sharma1 "Human Endothelial Progenitor Cells (EPCs) role in Tumor Angiogenesis49th Annual Meeting - The American Society for Cell Biology (2009) 
    View abstract... pdf - View Poster... 


Induced Pluripotent Cells (iPC's):

  • J. Sharma1, S. Kaushal2, R. Punzalan1, H. Uppal3, C. DiMaggio1, N. Taw1, M. Majdoub1, N. Liles1, G. Velazquez1, S. Sharma1, C. Sharma1, N. Amezcua1, M. Sharma1"Human Fibroblast / Keratinocyte De-differentiation into Human Cardiomyocytes in Tissue culture.49th Annual Meeting - The American Society for Cell Biology (2009) View abstract... pdf - View Poster... 

Patent:

  • Method of Treating Lactose Intolerance Using Genetically Engineered Bacteria  View Article