Product Description
Multilineage-differentiating stress-enduring (Muse) cells are endogenous, non-tumorigenic pluripotent stem cells found in adult connective tissues and bone marrow. They are identified by SSEA-3 surface markers, possess high stress tolerance, and can differentiate into tissues from all three germ layers (endoderm, mesoderm, ectoderm) to repair damage. Muse cells are a promising, non-immunogenic, and safe tool for regenerative medicine, able to migrate to injured sites via blood without forming teratomas.
Source: Found in bone marrow, peripheral blood, connective tissue, and adipose tissue (fat).
Positive Markers:
Surface Marker: SSEA-3 is the primary identifying marker for positive selection, with Muse cells being double-positive for SSEA-3 and CD105.
Pluripotency Markers: Expresses transcriptional factors Nanog, Oct3/4, and Sox2.
Mesenchymal Markers: Positive for CD105, CD29, and CD90.
Frozen Vial :shipped with 1.2 Million Cells; upon thawing 1.0 million cells after a freeze thaw cycle.
Cells are provided at passage number 2, and can be cultured up to 12 passages provided they are cultured in their appropriate media and ECM pre-coated tissue culture ware.
Unique Migration: Muse cells detect signals from injured tissues (S1P, sphingosine-1-phosphate) and travel through the bloodstream to specifically target and repair damaged areas.
Pluripotency without Tumors: While they exhibit pluripotency similar to embryonic stem cells (ESCs), Muse cells do not form teratomas (tumors) because they possess low telomerase activity and a natural "fail-safe" mechanism.
Immune Privilege: They exhibit strong anti-immune mechanisms (e.g., HLA-G expression), allowing for transplantation without requiring strict HLA matching or immunosuppressants.
Self-Renewal and Repair: Muse cells repair tissue by replacing damaged/apoptotic cells, acting as a natural repair system.
